User blog comment:FairyRaven/Fairy Tail Chapter 465: 400 Years, Review and Commentary/@comment-114.108.214.205-20151209150638/@comment-7418318-20151210134315

With Gray, Makarov (though granted, his survival was on Tenrou... so not really a good example) and Jiemma surviving similarly sized holes in their belly or chests respectively, I wouldn't completely rule out the possibility that Brain/Zero could still be alive.