User blog comment:Omega natsu2/Future Matchups!/@comment-1359322-20140414000027/@comment-7418318-20140414115108

I wouldn't be surprised if the Spirits are immune or at least resistant to Macro, but Sayla could still just take over Lucy's body terminate the magic flow that keeps the Spirits' gates open.

So unless Lucy hides out of sight and sends only her spirits in to fight (something I really can't see her doing) or she hides within Horologium the entire time with another spirit doing the fighting (again I don't think she'd do that), there's little to no chance for Lucy to win this.

And that's not even considering that it's highly doubtful that her spirits could keep up with Sayla's physical battle prowess once she released her limiters.