User blog comment:IamJakuhoRaikoben/Chapter 446: The Land Abandoned By God, Review./@comment-24228963-20150727113435

About Brandish being related to Karen, I think so too. I also made a theory about it before. Their hair color and clothing style just have the same feel to it. She's probably the reason why Karen was filled with anger and hatred. They might be sisters and she left her.