User blog comment:GotMilk5101520/How will the Tartarus Arc Part 4 will end?/@comment-7418318-20140710223028

The only thing that can destroy E.N.D. is Plue's nose/horn. And in the final battle of the arc, Lucy will summon Saggitarius and Plue. While the other members of Fairy Tail hold the Demon still for a moment, Saggitarius uses his bow to fire Plue. The nose/horn pierces the Demon's heart and after some final ominous words about Zeref and Acnologia E.N.D. dies. :P