User blog comment:IamJakuhoRaikoben/Chapter 376: Wendy vs. Ezel, Review./@comment-4449950-20140321014355/@comment-7418318-20140322220128

While E.N.D. was said to be the guild master we haven't seen it issue any orders. Right now it looks like Kyouka is calling the shots in Tartaros, so I think she would qualify as a female Dark Mage leader (thought he 'Mage' isn't exactly true).

I'm actually hoping that E.N.D. will be something that has moved beyond such trivial matters as gender. Reproduction is something that isn't needed in a bio-weapon, so any gender-specific features are also superfluous.